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Last modified by Ryan C on 2025/06/26 03:09
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edited by Ryan C
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To version 5.1
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51 -= Study: Genetic Structure, Self-Identified Race/Ethnicity, and Confounding =
52 -{{expand expanded="false" title="Click here to expand details"}}
53 -**Source:** Journal of Genetic Epidemiology
54 -**Date of Publication:** 2024-01-15
55 -**Author(s):** Smith et al.
56 -**Title:** "Genetic Structure, Self-Identified Race/Ethnicity, and Confounding in Case-Control Association Studies"
57 -**DOI:** [https://doi.org/10.1037/1076-8971.11.2.235](https://doi.org/10.1037/1076-8971.11.2.235)
58 -**Subject Matter:** Genetics, Social Science
59 59  
60 -**Tags:** `Genetics` `Race & Ethnicity` `Biomedical Research`
61 -
62 -=== **Key Statistics** ===
63 -
64 -1. **General Observations:**
65 - - A near-perfect alignment between self-identified race/ethnicity (SIRE) and genetic ancestry was observed.
66 - - Misclassification rate: **0.14%**.
67 -
68 -2. **Subgroup Analysis:**
69 - - Four groups analyzed: **White, African American, East Asian, and Hispanic**.
70 - - Hispanic genetic clusters showed significant European and Native American lineage.
71 -
72 -=== **Findings** ===
73 -
74 -- Self-identified race strongly aligns with genetic ancestry.
75 -- Minor discrepancies exist but do not significantly impact classification.
76 -
77 -=== **Relevance to Subproject** ===
78 -
79 -- Reinforces the reliability of **self-reported racial identity** in genetic research.
80 -- Highlights **policy considerations** in biomedical studies.
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