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	51	+= Study: Genetic Structure, Self-Identified Race/Ethnicity, and Confounding =
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	53	+**Source:** Journal of Genetic Epidemiology
	54	+**Date of Publication:** 2024-01-15
	55	+**Author(s):** Smith et al.
	56	+**Title:** "Genetic Structure, Self-Identified Race/Ethnicity, and Confounding in Case-Control Association Studies"
	57	+**DOI:** [https://doi.org/10.1037/1076-8971.11.2.235](https://doi.org/10.1037/1076-8971.11.2.235)
	58	+**Subject Matter:** Genetics, Social Science
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	60	+**Tags:** `Genetics` `Race & Ethnicity` `Biomedical Research`
	61	+
	62	+=== **Key Statistics** ===
	63	+
	64	+1. **General Observations:**
	65	+ - A near-perfect alignment between self-identified race/ethnicity (SIRE) and genetic ancestry was observed.
	66	+ - Misclassification rate: **0.14%**.
	67	+
	68	+2. **Subgroup Analysis:**
	69	+ - Four groups analyzed: **White, African American, East Asian, and Hispanic**.
	70	+ - Hispanic genetic clusters showed significant European and Native American lineage.
	71	+
	72	+=== **Findings** ===
	73	+
	74	+- Self-identified race strongly aligns with genetic ancestry.
	75	+- Minor discrepancies exist but do not significantly impact classification.
	76	+
	77	+=== **Relevance to Subproject** ===
	78	+
	79	+- Reinforces the reliability of **self-reported racial identity** in genetic research.
	80	+- Highlights **policy considerations** in biomedical studies.
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